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sickle cell (anemia 或 disease) 【醫學】鐮形血球(...

sickle feather

The sickle cell mutation today can be found in five different haplotypes , leading to the conclusion that the mutation appeared independently five times in five different founders . ( although sickle cell disease usually results from a founder mutation , some cases do arise from other mutations 科學家發現,現今的鐮狀細胞突變分別座落于五個不同的單純型之中,顯見這種突變曾獨立出現過五次,各自發生在五個不同的創始者身上(雖然鐮狀細胞貧血癥通常是因創始者突變,但也有些病例是其他不同的突變所造成的) 。

Travelers with underlying medical conditions , such as congestive heart failure , myocardial ischemia ( angina ) , sickle cell disease , or any form of pulmonary insufficiency , should be advised to consult a doctor familiar with high - altitude illness before undertaking such travel 具有下列病癥,如郁血性心衰竭、心絞痛、鐮刀型紅血球疾病或任何形式肺功能不全的旅者,應在成行前諮詢熟稔高山疾病的醫師。

Sickle cell disease is a group of inherited disorders of the hemoglobin molecule which , when exposed to various conditions ( to be discussed later this week ) , cause the red blood cell hemoglobin to polymerize and distort the cell into a sickle shape 鐮狀細胞病是一種遺傳性血紅蛋白分子功能紊亂疾患,當血紅蛋白分子暴露在各種環境中(以后將討論) ,紅細胞血紅蛋白發生聚合,扭曲變形成鐮狀。

Strokes have been noted to occur at an early age , with 8 % of patients with sickle cell anemia affected by age 14 , with 80 % of these strokes resulting in complete occlusion of at least 1 major cerebral vessel ( 5 ) 研究表明中風多發生在疾患早期, 8 %的鐮狀細胞性貧血患者發生在14歲時,而這些中風的80 %造成了至少一條重要腦血管完全堵塞[ 5 ] 。

Though in early childhood the spleen may be enlarged with sickle cell anemia , continual stasis and trapping of abnormal rbc ' s leads to infarctions that eventually reduce the size of the spleen tremendously by adolescence 雖然在兒童早期鐮狀細胞貧血可導致脾增大,但在青春期由于異常的rbc持續的郁積和阻塞,引起脾梗死,脾體積明顯縮小。

Vaso - occlusive pain crises ( vpc ) have been defined as the occurrence of pain in the extremities , back , abdomen , chest , or head that lasts 2 or more hours and cannot be explained except by the presence of sickle cell disease ( 1 ) Vpc是指四肢、背部、腹部、胸部或頭部出現疼痛,持續兩小時以上,且不能為鐮狀細胞病以外的疾患所解釋[ 1 ] 。

Sickle cell disease is usually found among people of largely african or mediterranean descent , for instance , whereas cystic fibrosis is far more common among those of european ancestry 例如在美國,鐮狀紅血球的病例主要在非洲裔、地中海裔族群中出現,而罹患囊腫性纖維化疾病的人,在歐洲裔族群中最常見。

This being said , the use of epidural analgesia has been observed to result in favorable recovery in patients with lower abdominal and extremity sickle cell crises ( 6 ) 如此而言,硬膜外鎮痛的使用可使患者下腹部和遠端部位鐮狀細胞危象得到有效的改善[ 6 ] 。

Sickle cell disorders affect a significant international population , primarily of african descent , but also mediterranean , middle eastern , and south east asian populations ( 3 ) 鐮狀細胞紊亂在國際上流行甚廣,主要集中于非洲、地中海、中東和東南亞[ 3 ] 。

Sickle cell disease is a common genetic disorder . this week we ' ll discuss the disease and its implications for anesthesia . today we ' ll discuss the genetics of the disorder 鐮狀細胞病是一種常見的遺傳病。本周我們討論與本病麻醉相關的一些問題。

Sickle cell disease is any sickle cell disorder in which significant morbidity occurs , such as vaso - occlusive pain crisis ( vpc ) or organ dysfunction 鐮狀細胞病是一類高死亡率的鐮狀細胞紊亂,如血管阻塞性疼痛危象( vpc )或器官功能紊亂。

Transfusions are usually not required nor recommended for standard vaso - occlusive crises or pain associated with sickle cell disease 對于鐮狀細胞病相關的標準血管阻塞性危象或疼痛,輸血治療常沒有必要,且不推薦使用。

Transfusions are usually not required nor recommended for standard aso - occlusie crises or pain associated with sickle cell disease 對于鐮狀細胞病相關的標準血管阻塞性危象或疼痛,輸血治療常沒有必要,且不推薦使用。

Fixing infertility genes , he hopes , would be just a first step toward correcing genetic diseases like sickle cell anemia 他希望,修復不育基因只是治療鐮狀細胞性貧血等基因疾病的開始。

The sickle cell mutation apparently arose repeatedly in regions riddled with malaria in africa and the middle east 鐮狀細胞的突變在瘧疾肆虐的非洲和中東等區域,顯然曾重復發生過多次。

Perhaps the best - known example of a double - edged genetic mutation is the one responsible for sickle cell disease 鐮狀細胞貧血癥大概是這些利弊互存的遺傳疾病中,最著名的例子。

Sickle cell anemia represents patients who are homozygous for hemoglobin s ( i . e . hemoglobin ss ) 鐮狀細胞性貧血是指血紅蛋白s為純合子的患者(如血紅蛋白ss ) 。

These disorders may include cystic fibrosis , hemophilia , sickle cell anemia , and many others 這些變異包括包囊纖維癥、血友病、鐮狀細胞貧血癥和其他多種疾病。

Persons with sickle cell trait ( hemoglobin as ) are much less likely to have this happen 帶有鐮狀細胞特性(血紅蛋白as )的人并不常發生這種情況。